Dr. Ruel is Professor and Chief of the Division of Pediatric Infectious Diseases and Global Health in the Department of Pediatrics in University of California, San Francisco Benioff Children’s Hospitals. His long-term career goal is to optimize the health outcomes of infant and children affected by HIV. He currently serves as co-chair of the NIH/DHHS Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children that publishes treatment guidelines for children in the USA, and co-chair to the Pediatric Antiretroviral Working Group at the World Health Organization. His research activities include clinical trials to evaluate the pharmacokinetics, safety and efficacy of antiretroviral medications in children, as well as implementation science to evaluate approaches to prevent vertical transmission of HIV and to improve outcomes in adolescents and young adults living with HIV. Within the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT), he is Chair of the Treatment Scientific Committee.  In San Francisco, he cares for children living with HIV, as well as parents living with HIV and their infants.